RFA-CA-27-017: The Experimental Therapeutics Clinical Trials Network (ETCTN) Pharmacokinetic Resource Laboratory (U24 Clinical Trial Not Allowed)
Sponsor: NCIInternal Deadline: 06/19/2026Institutional Submission Limit: 1Sponsor Deadline: 06/30/2026Program Website
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications from institutions/organizations that propose to maintain or establish a Pharmacokinetics Resource Laboratory (PK Laboratory) to support the Experimental Therapeutics Clinical Trials Network (ETCTN). The PK Laboratory will organize biospecimen collections and provide subsequent analyses of pharmacokinetic endpoints, drug-drug interactions, cytochrome P450 (CYP) interactions, pharmacodynamics, and food effects in ETCTN studies of NCI Investigational New Drug (IND) agents.
The overarching goal of the ETCTN PK Laboratory is to advance the clinical development of NCI IND agents by providing a comprehensive understanding of pharmacokinetic behavior of these agents under study in ETCTN trials. The ETCTN PK Laboratory will engage physicians, clinical pharmacologists, nurses, and scientists who have appropriate expertise in pharmacokinetic studies for early drug development and translational research. This NOFO seeks U24 applications from multidisciplinary institutions/organizations to conduct all pharmacokinetic studies for ETCTN early phase clinical trials filed to IND applications in the NCI Division of Cancer Treatment and Diagnosis (DCTD), Cancer Therapy Evaluation Program (CTEP).
Only one application per institution (normally identified by having a unique UEI or NIH IPF number) is allowed.
Submission Process
Limited submissions MUST be coordinated with the Office of the Vice President for Research.
If interested in applying for this opportunity, please combine the following items into a single PDF and email to resdev@mailbox.sc.edu by 5pm on the INTERNAL DEADLINE above:
- Cover page with grant program name & number (if applicable) to which you are applying, your project title, PI (name, department/unit, & email), and list of co-PIs/key collaborators (name & department/unit)
- a two-page project abstract addressing key components/criteria for this specific grant program
- a 2-3 page CV/biosketch for the PI (SCiENcv preferred)